Physiologically Based Pharmacokinetic Modeling of Nanoparticles

Rapid expansion of nanoparticle research demands new technologies that will enable better Interpretation of experimental data and assistance in the rational design of future nanoparticles The use of Models have been successfully applied for the study Of the absorption, distribution, metabolism, and excretion (ADME) of small molecules, such as drugs preliminary application of PBPK models to nanoparticles illustrated their. potential usefulness for nanoparticle ADME research However, due to the differences between nanoparticles and small Molecules, modification are needed to build appropriate PBPK models for nanoparticles This review is divided into two sections, with the first discussing nanoparticle ADME research emphasizing the interaction of nanoparticles with living systems including transportation kinetic across biobarriers In the second section, the basic principles of PBP model development are introduced, and research pertaining to PBPK models of nanoparticles is reviewed Factors that need to be considered for developing PBPK models for nanoparticles are also discussed Finally, perspective applications of nanoparticle PBPK models are summarized