Journal
ACS NANO
Volume 4, Issue 9, Pages 4971-4978Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn100560p
Keywords
liposomes; polymers; breast cancer; pH-responsive release; in vivo drug delivery
Categories
Funding
- NIH (NCI Center of Cancer Nanotechnology Excellence [U54CA119341, P30CA060553]
- Rosenberg Family Cancer Research Fund
- CD-MRP Breast Cancer Research [BC073413]
Ask authors/readers for more resources
A series of doxorubicin-loaded polymer-caged nanobins (PCNDXR) were evaluated in vivo in a murine MDA-MB-231 xenograft model of triple-negative breast cancer. The cross-linked polymer cage in PCNDXR offers protection for the drug payload while serving as a pH-responsive trigger that enhances drug release in the acidic environments commonly seen in solid tumors and endosomes. Varying the degree of cross-linking in the polymer cage allows the surface potential of PCNDXR, and thus the in vivo circulation lifetime of the nanocarriers, to be tuned in a facile fashion. Given these design advantages, the present study provides the first in vivo evidence that PCNDXR can effectively inhibit tumor growth in a murine model of breast cancer. Importantly, PCNDXR was well-tolerated by mice, and drug encapsulation attenuated the toxicity of free doxorubicin. Taken together, this study demonstrates the potential utility of the PCN platform in cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available