Journal
ACS NANO
Volume 4, Issue 6, Pages 3215-3221Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn100274v
Keywords
magnetoliposome; SPIO nanoparticle; self-assembly; lipid bilayer; drug delivery
Categories
Funding
- National Science Foundation (CBET) [0619440, 0828022, 0931875]
- NASA
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0828022, 0619440] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0931875] Funding Source: National Science Foundation
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Nanoscale assemblies that can be activated and controlled through external stimuli represent a next stage in multifunctional therapeutics. We report the formation, characterization, and release properties of bilayer-decorated magnetoliposomes (dMLs) that were prepared by embedding small hydrophobic SPIO nanoparticles at different lipid molecule to nanoparticle ratios within dipalmitoylphosphatidylcholine (DPPC) bilayers. The dML structure was examined by cryogenic transmission electron microscopy and differential scanning calorimetry, and release was examined by carboxyfluorescein leakage. Nanoparticle heating using alternating current electromagnetic fields (EMFs) operating at radio frequencies provided selective release of the encapsulated molecule at low nanoparticle concentrations and under physiologically acceptable EMF conditions. Without radio frequency heating, spontaneous leakage from the dMLs decreased with increasing nanoparticle loading, consistent with greater bilayer stability and a decrease in the effective dML surface area due to aggregation. With radio frequency heating, the initial rate and extent of leakage increased significantly as a function of nanoparticle loading and electromagnetic field strength. The mechanism of release is attributed to a combination of bilayer permeabilization and partial dML rupture.
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