Journal
ACS NANO
Volume 3, Issue 3, Pages 744-752Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn900001q
Keywords
fluorescence enhancement; IR800; gold nanoshells; gold nanorods; frequency domain lifetime decay
Categories
Funding
- Robert A. Welch Foundation [C-1220]
- Air Force Office of Scientific Research [F49620-03-C-0068]
- Multidisciplinary University Research Initiative [W911NF-04-01-0203]
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Metallic nanoparticles influence the quantum yield and lifetime of adjacent fluorophores in a manner dependent on the properties of the nanostructure. Here we directly compare the fluorescence enhancement of the near-infrared fluorophore IR800 by All nanoshells (NSs) and Au nanorods (NRs), where human serum albumin (HSA) serves as a spacer layer between the nanoparticle and the fluorophore. Our measurements reveal that the quantum yield of IR800 is enhanced from similar to 7% as an isolated fluorophore to 86% in a NSs-HSA-IR800 complex and 74% in a NRs-HSA-IR800 complex. This dramatic increase in fluorescence shows tremendous potential for contrast enhancement in fluorescence-based bioimaging.
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