Journal
ACS NANO
Volume 3, Issue 7, Pages 2016-2022Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn900480m
Keywords
nanodiamond; nanomedicine; chemotherapy; breast cancer; liver cancer
Categories
Funding
- National Science Foundation CAREER Award [CMMI-0846323]
- National Science Foundation Mechanics of Materials program [CMMI-0856492]
- V Foundation for Cancer Research V Scholars Award
- National Science Foundation Center for Scalable and Integrated NanoManufacturing (SINAM) [DMI-0327077]
- Wallace H. Coulter Foundation Early Career Award in Translational Research
- National Science Foundation National Center for Learning & Teaching in Nanoscale Science and Engineering (NCLT)
- National Institutes of Health [U54 A1065359]
- Weinberg College of Arts and Sciences of Northwestern University
- Directorate For Engineering [0751621] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0856492] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [0751621] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0846323] Funding Source: National Science Foundation
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A broad array of water-insoluble compounds has displayed therapeutically relevant properties toward a spectrum of medical and physiological disorders, including cancer and inflammation. However, the continued search for scalable, facile, and biocompatible routes toward mediating the dispersal of these compounds in water has limited their widespread application in medicine. Here we demonstrate a platform approach of water-dispersible, nanodiamond cluster-mediated interactions with several therapeutics to enhance their suspension in water with preserved functionality, thereby enabling novel treatment paradigms that were previously unrealized. These therapeutics include Purvalanol A, a highly promising compound for hepatocarcinoma (liver cancer) treatment, 4-hydroxytamoxifen (4-CHT), an emerging drug for the treatment of breast cancer, as well as dexamethasone, a clinically relevant anti-inflammatory that has addressed an entire spectrum of diseases that span complications from blood and brain cancers to rheumatic and renal disorders. Given the scalability of nanodiamond processing and functionalization, this novel approach serves as a facile, broadly impacting and significant route to translate water-insoluble compounds toward treatment-relevant scenarios.
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