Journal
ACS NANO
Volume 3, Issue 10, Pages 2919-2926Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn900215k
Keywords
chemo-photothermal treatment; NIR resonance; doxorubicin; synergistic effect
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Funding
- Korea Science and Engineering Foundation through National Core Research Center for Nanomedical Technology [R15-20040924-00000-0]
- National Research Foundation of Korea [과06A1104, 과C6A1905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing All films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.
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