Journal
ACS NANO
Volume 3, Issue 7, Pages 1877-1885Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn900451a
Keywords
(-)-epigallocathechin gallate; EGCG; tannic acid; theaflavin; gelatin nanoparticles; layer-by-layer assembly; polyelectrolytes; encapsulation and release; HGF; intracellular signaling; tumor cells
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Funding
- NSF-EPSCoR [34768]
- NSF [0508560]
- NIH [R01-CA104242]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0508560] Funding Source: National Science Foundation
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Natural polyphenols with previously demonstrated anticancer potential, epigallocatechin gallate (EGCG), tannic acid, curcumin, and theaflavin, were encased into gelatin-based 200 nm nanoparticles consisting of a soft gel-like interior with or without a surrounding LbL shell of polyelectrolytes (polystyrene sulfonate/polyallylamine hydrochloride, polyglutamic acid/poly-L-lysine, dextran sulfate/protamine sulfate, carboxymethyl cellulose/gelatin, type A) assembled using the layer-by-layer technique. The characteristics of polyphenol loading and factors affecting their release from the nanocapsules were investigated. Nanoparticle-encapsulated EGCG retained its biological activity and blocked hepatocyte growth factor (HGF)-induced intracellular signaling in the breast cancer cell line MBA-MD-231 as potently as free EGCG.
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