Bioactive SrTiO3 Nanotube Arrays: Strontium Delivery Platform on Ti-Based Osteoporotic Bone Implants

Development of strontium releasing implants capable of stimulating bone formation and inhibiting bone resorption is a desirable solution for curing osteoporosis. In this work, well-ordered SrTiO3 nanotube arrays capable of Sr release at a slow rate and for a long time are successfully fabricated on titanium by simple hydrothermal treatment of anodized titania nanotubes. This surface architecture combines the functions of nanoscaled topography and Sr release to enhance osseointegration while at the same time leaving space for loading of other functional substances. In vitro experiments reveal that the SrTiO3 nanotube arrays possess good biocompatibility and can induce precipitation of hydroxyapatite from simulated body fluids (SBF). This Ti-based implant with SrTiO3 nanotube arrays is an ideal candidate for osteoporotic bone implants. The proposed method can also be extended to load other biologically useful elements such as Mg and Zn.