Journal
ACS NANO
Volume 2, Issue 5, Pages 889-896Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn800072t
Keywords
mesoporous silica; iron oxide; dual imaging; drug delivery; multifunctional
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Funding
- NCI NIH HHS [CA32737, P01 CA032737, P01 CA032737-18A20003] Funding Source: Medline
- NIEHS NIH HHS [R01 ES015498, R01 ES010553, ES10553, R01 ES10253] Funding Source: Medline
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Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.
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