Journal
ACS NANO
Volume 2, Issue 7, Pages 1466-1472Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn8001517
Keywords
lipid tubules; atomic force microscopy; finite element analysis; nanomechanics
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Self-assembled lipid tubules with crystalline bilayer walls represent useful supramolecular architectures which hold promise as vehicles for the controlled release of preloaded drugs and templates for the synthesis of one-dimensional inorganic materials. We study the local elasticity of lipid tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine by radial atomic force microscope indentation, coupled with finite element analysis. A reduced stiffness is found to extend a distance of similar to 600 nm from the ends of lipid tubules. The middle section of lipid tubules is homogeneous in terms of their radial elasticity with a Young's modulus of similar to 703 MPa. The inhomogeneous radial elasticity likely arises from the variation of lipid packing density near the tubule ends.
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