Journal
ACS NANO
Volume 2, Issue 11, Pages 2273-2282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn8004476
Keywords
nanoparticles; polysiloxane shell; bioconjugation; streptavidin; fibronectin
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Funding
- Agence Nationale de la Recherche [ANR-05-NANO-037-02]
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For labeling proteins (streptavidin and fibronectin) by luminescent aminated nanoparticles, an interesting strategy that requires neither activation nor chemical pre- or post-treatment was explored. Because biomolecules are easily rendered luminescent after reaction with organic dyes carrying isothiocyanate moiety, phenylene diisothiocyanate (DITC) was used for covalently binding proteins onto luminescent hybrid gadolinium oxide nanoparticles whose ability to combine imaging and therapy was recently demonstrated.
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