Journal
ACS CHEMICAL NEUROSCIENCE
Volume 4, Issue 4, Pages 519-526Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn300191b
Keywords
Focused ultrasound; blood-brain barrier; drug delivery
Funding
- National Institutes of Health [R01 EB003268]
- Canadian Institutes for Health Research [FRN 119312]
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Brain diseases are notoriously difficult to treat due to the presence of the blood-brain barrier (BBB). Here, we review the development of focused ultrasound (FUS) as a noninvasive method for BBB disruption, aiding in drug delivery to the brain. FUS can be applied through the skull to a targeted region in the brain. When combined with microbubbles, FUS causes localized and reversible disruption of the BBB. The cellular mechanisms of BBB disruption are presented. Several therapeutic agents have been delivered to the brain resulting in significant improvements in pathology in models of glioblastoma and Alzheimer's disease. The requirements for clinical translation of FUS will be discussed.
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