Journal
ACS CHEMICAL NEUROSCIENCE
Volume 3, Issue 8, Pages 577-584Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn300065j
Keywords
Channelrhodopsin; archaerhodopsin; halorhodopsin; cell type specificity
Funding
- NIH [5R00MH085944, 1R01NS081716]
- Alfred P. Sloan Foundation
- Michael J. Fox Foundation
- Pew Charitable Trusts Foundation
- Boston University Biomedical Engineering Department
- Boston University Photonic Center
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1042134] Funding Source: National Science Foundation
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Optogenetics combines optical and genetic methods to rapidly and reversibly control neural activities or other cellular functions using genetic methods, specific cells or anatomical pathways can be sensitized to light through exogenous expression of microbial light activated opsin proteins. Using optical methods, opsin expressing cells can be rapidly and reversibly controlled by pulses of light of specific wavelength. With the high spatial temporal precision, optogenetic tools have enabled new ways to probe the causal role of specific cells in neural computation and behavior. Here, we overview the current state of the technology, and provide a brief introduction to the practical considerations in applying optogenetics in vivo to analyze neural circuit functions.
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