Journal
ACS CHEMICAL NEUROSCIENCE
Volume 2, Issue 10, Pages 555-567Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn2000537
Keywords
Adenosine; A(2A) receptor antagonist; A(1) receptor antagonist; Parkinson's disease; catalepsy; 6-OHDA; MPTP
Ask authors/readers for more resources
This Review summarizes and updates the work on adenosine A(2)A receptor antagonists for Parkinson's disease from 2006 to the present. There have been numerous publications, patent applications, and press releases within this time frame that highlight new medicinal chemistry approaches to this attractive and promising target to treat Parkinson's disease. The Review is broken down by scaffold type and will discuss the efforts to optimize particular scaffolds for activity, pharmacokinetics, and other drug discovery parameters. The majority of approaches focus on preparing selective A2A antagonists, but a few approaches to dual A(2A)/A(1) antagonists will also be highlighted. The in vivo profiles of compounds will be highlighted and discussed to compare activities across different chemical series. A clinical report and update will be given on compounds that have entered clinical trials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available