Journal
ACS CHEMICAL NEUROSCIENCE
Volume 2, Issue 10, Pages 568-571Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn2000525
Keywords
Aquaporin 4; positron emission tomography; C-11; TGN-020
Funding
- Ministry of Education, Culture, Sports, Science, and Technology (Japan)
- University of Niigata
Ask authors/readers for more resources
Aquaporin 4 (AQP4), the most abundant isozyme of the water specific membrane transporter aquaporin family, has now been implicated to play a significant role in the pathogenesis of various disease processes of the nervous system from epilepsy to Alzheimer's disease. Considering its clinical relevance, it is highly desirable to develop a noninvasive method for the quantitative analysis of AQP distribution in humans under clinical settings. Currently, the method of choice for such diagnostic examinations continues to be positron emission tomography (PET). Here, we report the successful development of a PET ligand for AQP4 imaging based on TGN-020, a potent AQP4 inhibitor developed previously in our laboratory. Utilizing [C-11]TGN-020, PET images were successfully generated in wild type and AQP4 null mice, providing a basis for future evaluation regarding its suitability for clinical studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available