Journal
ACS CHEMICAL BIOLOGY
Volume 8, Issue 6, Pages 1283-1290Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb400090d
Keywords
-
Categories
Funding
- American Chemical Society-Teva USA Scholar
- National Institutes of Health [R01GM088226, R01HL092141, R01HL093579, R01HL079040, P20HL113452, 5U24HL094373]
- Carlyle Fraser Heart Center of Emory University Hospital Midtown
Ask authors/readers for more resources
Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on H2S has been hindered due to the lack of controllable H2S releasing agents that could mimic the slow and moderate H2S release in vivo. In this work we report the design, synthesis, and biological evaluation of a new class of controllable H2S donors. Twenty-five donors were prepared and tested. Their structures were based on a perthiol template, which was suggested to be involved in H2S biosynthesis. H2S release mechanism from these donors was studied and proved to be thiol-dependent. We also developed a series of cell based assays to access their H2S-related activities. H9c2 cardiac rnyocytes were used M these experiments. We tested lead donors cytotoxicity and confirmed their H2S production in cells. Finally we demonstrated that selected donors showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfuSion injury, through a H2S-related mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available