Journal
ACS CHEMICAL BIOLOGY
Volume 9, Issue 1, Pages 111-115Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb400755b
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Funding
- National Institutes of Health [R01 GM073046, DP1 HD075622]
- Human Frontiers Science Program (HFSP) fellowship
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Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to nontoxic blue light. We demonstrate that fusion proteins containing this domain are rapidly degraded in cultured cells and in zebrafish upon illumination.
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