Journal
ACS CHEMICAL BIOLOGY
Volume 8, Issue 7, Pages 1640-1645Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb4001662
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- Chemistry Department of University of Nebraska-Lincoln
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM097206] Funding Source: NIH RePORTER
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We have utilized in vitro evolution to identify tRNA variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to a quadruplet codon in both bacterial and mammalian cells. This approach will facilitate the creation of an optimized and standardized system for the genetic incorporation of unnatural amino acids using quadruplet codons, which will allow the biosynthesis of biopolymers that contain multiple unnatural building blocks.
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