Journal
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
Volume 35, Issue 4, Pages 637-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2015.07.009
Keywords
Common variable immunodeficiency; CVID; Antibody deficiency; Primary immune deficiency; Immune activation; Autoimmunity; Lymphoproliferation
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Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of the numerous ways in which antibody production can be impaired and the frequency in which antibody production becomes impaired in human beings. CVID comprises a heterogeneous group of rare diseases. Consequently, CVID presents a significant challenge for researchers and clinicians. Despite these difficulties, both our understanding of and ability to manage this grouping of complex immune diseases has advanced significantly over the past 60 years.
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