Journal
ACS CHEMICAL BIOLOGY
Volume 7, Issue 1, Pages 31-43Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb2004466
Keywords
Carbohydrate; Glycan; Post-glycosylational modification; Sulfation; Phosphorylation; Acylation; Methylation
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Funding
- National Institutes of Health, NCI
- Pharmacology Research Associate (PRAT) of the NIGMS
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Carbohydrates play a central role in a wide range of biological processes. As with nucleic acids and proteins, modifications of specific sites within the glycan chain can modulate a carbohydrate's overall biological function. For example, acylation, methylation, sulfation, epimerization, and phosphorylation can occur at various positions within a carbohydrate to modulate bioactivity. Therefore, there is significant interest in identifying discrete carbohydrate modifications and understanding,their biological effects. Additionally, enzymes that catalyze those modifications and proteins that bind modified glycans provide numerous targets for therapeutic intervention. This review will focus on modifications of glycans that occur after the oligomer/polymer has been assembled, generally referred to as post-glycosylational modifications.
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