Journal
PSYCHIATRIC CLINICS OF NORTH AMERICA
Volume 34, Issue 2, Pages 335-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.psc.2011.02.005
Keywords
Late-life depression; Treatment algorithms; Novel treatment modalities
Categories
Funding
- NIMH NIH HHS [R01 MH083660, K23 MH 086686, K23 MH086686, P30 MH071944, P30 MH71944, R01 MH 083660] Funding Source: Medline
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As the population ages, successive cohorts of older adults will experience depressive disorders. Late-life depression (LLD) carries additional risk for suicide, medical comorbidity, disability, and family caregiving burden. Although response and remission rates to pharmacotherapy and electroconvulsive therapy are comparable with those in midlife depression, relapse rates are higher, underscoring the challenge to achieve and maintain wellness. This article reviews the evidence base for LLD treatment options and provides an analysis of treatment options for difficult-to-treat LLD variants (eg, psychotic depression, vascular depression). Treatment algorithms are also reviewed based on predictors of response and promising novel treatment options.
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