Journal
ACS CHEMICAL BIOLOGY
Volume 5, Issue 1, Pages 15-34Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb900249y
Keywords
Differentiation; Ectoderm; Endoderm; Embryonic stem cells; Feeder cells; Induced pluripotent stem cells; Mesoderm; Multipotent cells; Pluripotent cells; Totipotent cells
Categories
Funding
- National Institutes of Health [DP1 OD003792]
- NIH/NCI [R01 CA136574]
- NATIONAL CANCER INSTITUTE [R01CA136574] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD003792] Funding Source: NIH RePORTER
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Controlling cell fate is essential for embryonic development, tissue regeneration, and the prevention of human disease. With each cell in the human body sharing a common genome, achieving the appropriate spectrum of stem cells and their differentiated lineages requires the selective activation of developmental signaling pathways, the expression of specific target genes, and the maintenance of these cellular states through epigenetic mechanisms. Small molecules that target these regulatory processes are therefore valuable tools for probing and manipulating the molecular mechanisms by which stem cells self-renew, differentiate, and arise from somatic cell reprogramming. Pharmacological modulators of cell fate could also help remediate human diseases caused by dysregulated cell proliferation or differentiation, heralding a new era in molecular therapeutics.
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