Journal
ACS CHEMICAL BIOLOGY
Volume 4, Issue 6, Pages 409-427Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb900036s
Keywords
Phototysis; Photoisomerization; Caged compound; Quantum yield (Theta) of uncaging
Categories
Funding
- National Institutes of Health [NS048406, CA79954, GM086217, GM064346]
- Gruss Lipper Biophotonics Center
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Biological systems are characterized by a level of spatial and temporal organization that often ties beyond the grasp of present day methods. Light-modulated bioreagents, including analogs of low molecular weight compounds, peptides, proteins, and nucleic acids, represent a compelling strategy to probe, perturb, or sample biological phenomena with the requisite control to address many of these organizational complexities. Although this technology has created considerable excitement in the chemical community, its application to biological questions has been relatively limited. We describe the challenges associated with the design, synthesis, and use of light-responsive bioreagents; the scope and limitations associated with the instrumentation required for their application; and recent chemical and biological advances in this field.
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