Journal
ACS CHEMICAL BIOLOGY
Volume 4, Issue 8, Pages 603-616Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb9001409
Keywords
ABP; Bacterial toxin; Chemical genetics; Competitive ABPP; Gram staining; Protozoan parasites; Quorum sensing; Schizont; T3SS
Categories
Funding
- NIH [U54 RR020843, R01 EB005011, R01 AI078947]
- NSF
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Understanding the ways in which pathogens invade and neutralize their hosts is of great interest from both an academic and a clinical perspective. However, in Many cases genetic tools are unavailable,or insufficient to fully characterize the detailed mechanisms of pathogenesis. Small molecule approaches are particularly powerful due to their ability to modulate specific biological functions in a highly controlled manner and their potential to broadly target conserved processes across species. Recently, two approaches that make use of small molecules, activity-based protein profiling and high-throughput phenotypic screening, have begun to find applications in the study of pathways involved in pathogenesis. In this Review we highlight ways in which these techniques have been applied to examine bacterial and parasitic pathogenesis and discuss possible ways in which these efforts can be expanded in the near future.
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