Journal
ACS CHEMICAL BIOLOGY
Volume 4, Issue 2, Pages 93-107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb8002946
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Funding
- NIGMS NIH HHS [R01 GM072528-07, R01 GM072528] Funding Source: Medline
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Protein synthesis occurs in, ribosomes, the targets of numerous antibiotics. How these large and complex machines read and move along mRNA have proven to be challenging questions. In this Review, we focus on translocation, the last step of the elongation cycle in which movement of tRNA and mRNA is catalyzed by elongation factor G. Translocation entails large-scale movements of the tRNAs and conformational changes in the ribosome that require numerous tertiary contacts to be disrupted and reformed. We highlight recent progress toward elucidating the molecular basis of translocation and how various antibiotics influence tRNA-mRNA movement.
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