Journal
ACS CHEMICAL BIOLOGY
Volume 3, Issue 8, Pages 471-479Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cb800067e
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Takeda Science Foundation
- Global COE Program for Chemistry Innovation
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Specific targeting of disease cells has the potential of far-reaching applications, such as diagnostic imaging and therapies of diseases. Here we describe a novel method for selective targeting of a type of cells among various cell types. Activated macrophages are disease cells related to initiation and progression of atherosclerosis. We developed a molecular probe of which uptake into cells is synergistically activated by scavenger receptor class A type I (SR-AI) and matrix metalloproteinase-9 (MMP-9), which are the marker receptor and the marker protease of atherosclerosis, respectively. We demonstrated that the present targeting probe is selectively incorporated into activated macrophages expressing both SR-AI and the activated form of MMP-9 but not into resting macrophages having only SR-AI. The present approach may provide a powerful tool for cell-specific imaging and therapies.
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