Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 40, Pages 33879-33890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b10072
Keywords
silk sericin; 3D printing; interpenetrating polymer networks; transparent wound dressing
Funding
- National Nature Science Foundation of China [51403116]
- Natural Science Foundation of Guangdong Province [2015A030313698]
- Major Projects of PLA Logistics Research Plan [AWS14C001]
- Shenzhen Science and Technology Projects [JCYJ20140419122040605, JCYJ20150402103811548]
Ask authors/readers for more resources
A wound dressing which can be convenient for real-time monitoring of wounds is particularly attractive and user-friendly. In this study, a nature-originated silk-sericin-based (SS-based) transparent hydro gel scaffold was prepared and evaluated for the visualization of wound care. The scaffold was fabricated from a hybrid interpenetrating-network (IPN) hydrogel composed of SS and methacrylic-anhydride-modified gelatin (Ge1MA) by 3D printing. The scaffold transformed into a highly transparent hydrogel upon swelling in PBS, and thus, anything underneath could be easily read. The scaffold had a high degree of swelling and presented a regularly macroporous structure with pores around 400 mu m X 400 mu m, which can help maintain the moist and apinoid environment for wound healing. Meanwhile, the scaffolds were conducive to adhesion and proliferation of L929 cells. A coculture of HaCaT and HSF cells on the scaffold showed centralized proliferation of the two cells in distributed layers, respectively, denoting a promising comfortable environment for re-epithelialization. Moreover, in vivo studies demonstrated that the scaffold showed no excessive inflammatory reaction. In short, this work presented an SS-based transparent hydrogel scaffold with steerable physical properties and excellent biocompatibility through 3D printing, pioneering promising applications in the visualization of wound care and drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available