Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 38, Pages 31998-32005Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b11972
Keywords
metal-organic frameworks; endo/lysosomal escape; aptamer; intracellular environment-responsive; cancer therapy
Funding
- National Natural Science Foundation of China [21431007, 21533008, 21601175, 21871249, 21820102009]
- Key Program of Frontier of Sciences (CAS) [QYZDJ-SSW-SLH052]
Ask authors/readers for more resources
Nowadays, efficient endo/lysosomal escape and the subsequent release of drugs into the cytosol are the major obstacles for nanoplatform-based cancer therapy. Herein, we first report a metal-organic framework-based nanoplatform (doxorubicin@ZIF-8@AS1411) for intracellular environment-responsive endo/lysosomal escape and enhanced cancer therapy. In our system, the nanoplatform was first targeted toward the cancer cells. Then, it was entrapped in endo/lysosomes, where pH-responsive decomposition occurred and abundant Zn ions were released. The released Zn ions could induce an influx of counterions, promote reactive singlet oxygen (ROS) generation to rupture the endo/lysosomal membrane, and accelerate the release of anticancer drugs in the cytosol. Finally, the released drugs and the generation of ROS could synergistically enhance cancer therapy. With excellent biocompatibility, effective endo/lysosomal escape, and enhanced therapeutic effect, the novel drug delivery systems are supposed to become a promising anticancer agent for cancer therapy and bring more opportunities for biomedical application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available