Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 33, Pages 27578-27583Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b09511
Keywords
self-assembly; nanostructures; microfluidics; controlled release
Funding
- 622 the European Research Council under the European Union's 623 Seventh Framework Programme (FP7/2007-2013) through the 624 ERC Grant PhysProt [337969]
- EMBO
- FEBS
- Frances and Augustus Newman Foundation
- Tel Aviv Univesity Center for Nanoscience and Nanotechnology
- Swiss National Science Foundation
- Peterhouse Cambridge
- Israeli National Nanotechnology Initiative
- Helmsley Charitable Trust
- UK BBSRC
- BBSRC [BB/J002119/1] Funding Source: UKRI
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The release of nanoscale structures from microcapsules, triggered by changes in the capsule in response to external stimuli, has significant potential for active component delivery. Here, we describe an orthogonal strategy for controlling molecular species' release across oil/water interfaces by modulating their intrinsic self-assembly state. We show that although the soluble peptide Boc-FF can be stably encapsulated for days, its self-assembly into nanostructures triggers jet-like release within seconds. Moreover, we exploit this self-assembly-mediated release to deliver other molecular species that are transported as cargo. These results demonstrate the role of self-assembly in modulating the transport of peptides across interfaces.
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