Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 7, Pages 5212-5220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am5005267
Keywords
tetraphenylethene; self-assembly micelle; aggregation-induced emission; imaging; drug delivery
Funding
- State High-Tech Development Plan [2012AA020804]
- National Natural Science Foundation of China [30970784, 31170873, 81171455, 31225009]
- National Key Basic Research Program of China [2009CB930200]
- Chinese Academy of Sciences (CAS) Hundred Talents Program [07165111ZX]
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Nanoformulations show many therapeutic advantages over conventional formulations. We seek to develop traceable nanoformulations in order to closely monitor delivery. Herein, we developed a new drug delivery system (DDS) using tetraphenylethene (TPE) to fabricate a self-assembly micelle with aggregation-induced emission (AIE micelle). AIE makes the nanocarriers visible for high-quality imaging, and the switching on and off of the ME is intrinsically controlled by the assembly and disassembly of the micelles. This DDS was tested for doxorubicin (DOX) delivery and intracellular imaging. For the DOX-loaded micelles (TPED), the DOX content reached as much as 15.3% by weight, and the anticancer efficiency was higher than for free DOX. Meanwhile, high-quality imaging was obtained to trace the intracellular delivery of the TPED.
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