Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 8, Pages 5379-5382Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am5010909
Keywords
graphene; Alzheimer's disease; resveratrol; amyloid beta; fluorogenic; detection
Funding
- 973 project [2013CB733700]
- National Science Fund for Distinguished Young Scholars [81125023]
- National Natural Science Foundation of China [21176076, 21202045, 81173033]
- Key Project of Shanghai Science and Technology Commission [13NM1400900]
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Developing an effective means for the real-time probing of amyloid beta (A beta) that is closely implicated in Alzheimer's disease (AD) could help better understand and monitor the disease. Here we describe an economic approach based on the simple composition of a natural product, resveratrol (Res), with graphene oxide (GO) for the rapid, fluorogenic recognition of A beta. The Res@GO composite has proved specific for A beta over a range of proteins and ions, and could sensitively capture both A beta monomers and fibers in a physiological buffer solution within only 3 min. The composite can also fluorescently image amyloid deposits in a mouse brain section within 30 min. This new protocol is much cheaper and more timesaving than the conventional immunofluorescence staining technique employed clinically, providing an economic tool for the concise detection of AD.
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