Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 1, Pages 250-255Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am507680u
Keywords
layer-by-layer; autonomous propulsion; rocket; biodegradation; drug release
Funding
- National Nature Science Foundation of China [91027045, 21103034]
- Fundamental Research Funds for the Central Universities
- China Postdoctoral Science Foundation
- State Key Laboratory of Robotics and System (HIT)
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We describe a biodegradable, self-propelled bovine serum albumin/poly-l-lysine (PLL/BSA) multilayer rocket as a smart vehicle for efficient anticancer drug encapsulation/delivery to cancer cells and near-infrared light controlled release. The rockets were constructed by a template-assisted layer-by-layer assembly of the PLL/BSA layers, followed by incorporation of a heat-sensitive gelatin hydrogel containing gold nanoparticles, doxorubicin, and catalase. These rockets can rapidly deliver the doxorubicin to the targeted cancer cell with a speed of up to 68 mu m/s, through a combination of biocatalytic bubble propulsion and magnetic guidance. The photothermal effect of the gold nanoparticles under NIR irradiation enable the phase transition of the gelatin hydrogel for rapid release of the loaded doxorubicin and efficient killing of the surrounding cancer cells. Such biodegradable and multifunctional protein-based microrockets provide a convenient and efficient platform for the rapid delivery and controlled release of therapeutic drugs.
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