Journal
IMMUNOLOGICAL REVIEWS
Volume 269, Issue 1, Pages 228-247Publisher
WILEY
DOI: 10.1111/imr.12378
Keywords
Ncf1; NOX2; reactive oxygen species; inflammation; autoimmunity
Categories
Funding
- Swedish Foundation for Strategic Research
- Knut and Alice Wallenberg Foundation
- Swedish Science Research Council
- Guangdong Innovative and Entepreneurial Research Team Program
- EU
- EU Innovative Medicine Initiative BeTheCure grant
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The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease-promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex field from a new angle and with the possibilities to study the role of ROS invivo. We found that NCF1 and NADPH oxidase 2 (NOX2) complex-derived ROS is an important regulator of several chronic inflammatory disorders by using models for rheumatoid arthritis, multiple sclerosis, psoriasis and psoriasis arthritis, gout, and lupus. ROS could therefore affect many different types of diseases and the common denominator seems to be that ROS regulate macrophages, which prevents inflammation from going chronic. The role of ROS is currently changing from being seen as toxic agents that will promote inflammation toward a more complex view with ROS as crucial regulators of immune and inflammatory pathways.
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