Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 3, Pages 2131-2136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am405219u
Keywords
PEGylated silica nanoparticles; blood-brain barrier; different size; transportation
Funding
- National Basic Research Program of China [81101904, 21205100, 21275122]
- 973 Program of China [2010CB732402, 2013CB933703]
- National Instrumentation Program [2011YQ03012412]
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Transport of PEGylated silica nanoparticles (PSiNPs) with diameters of 100, 50, and 25 nm across the blood-brain barrier (BBB) was evaluated using an in vitro BBB model based on mouse cerebral endothelial cells (bEnd.3) cultured on transwell inserts within a chamber. In vivo animal experiments were further performed by noninvasive in vivo imaging and ex vivo optical imaging after injection via carotid artery. Confocal fluorescence studies were carried out to evaluate the uptake of PSiNPs by brain endothelial cells. The results showed that PSiNPs can traverse the BBB in vitro and in vivo. The transport efficiency of PSiNPs across BBB was found to be size-dependent, with increased particle size resulting in decreased efficiency. This work points to the potential application of small sized silica nanoparticles in brain imaging or drug delivery.
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