Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 23, Pages 21638-21644Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am506698f
Keywords
imaging agents; fluorescence; mitochondria; flavone; biocompatibility; wash-free
Funding
- National Institutes of Health [1R15EB014546]
- Coleman Endowment of The University of Akron
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Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and apoptosis mechanism.
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