Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 12, Pages 9897-9903Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am502729y
Keywords
micromotors; Janus particles; magnesium-water reaction; self-propulsion; autonomous motion; body fluid; blood plasma
Funding
- National Natural Science Foundation of China [51303144]
- Top Talents Lead Cultivation Project [2012FFB05101]
- Natural Science Foundation of Hubei Province [2012FFB05101]
- SKLWUT [2013-PY-3]
- Wuhan University of Technology [2013-PY-3]
- Fundamental Research Funds for the Central Universities [WUT: 2013-IV-089]
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In this work, we have demonstrated the autonomous motion of biologically-friendly Mg/Pt-Poly(N-isopropylacrylamide) (PNIPAM) Janus micromotors in simulated body fluids (SBF) or blood plasma without any other additives. The pit corrosion of chloride anions and the buffering effect of SBF or blood plasma in removing the Mg(OH)(2) passivation layer play major roles for accelerating Mg-H2O reaction to produce hydrogen propulsion for the micromotors. Furthermore, the Mg/Pt-PNIPAM Janus micromotors can effectively uptake, transport, and temperature-control-release drug molecules by taking advantage of the partial surface-attached thermoresponsive PNIPAM hydrogel layers. The PNIPAM hydrogel layers on the micromotors can be easily replaced with other responsive polymers or antibodies by the surface modification strategy, suggesting that the as-proposed micromotors also hold a promising potential for separation and detection of heavy metal ions, toxicants, or proteins.
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