Journal
IMMUNOLOGICAL REVIEWS
Volume 265, Issue 1, Pages 143-155Publisher
WILEY
DOI: 10.1111/imr.12279
Keywords
hepatitis; inflammasomes; proinflammatory cytokines; IL-1 and IL-18; innate immunity; inflammation
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Funding
- NIH [AI088778]
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Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis and is typically associated with chronic viral infection. Alcohol-induced and non-alcoholic steatohepatitis are two rising hepatic problems. The innate immune inflammasome signaling cascade mediates the production of essential proinflammatory cytokines interleukin-1 (IL-1) and IL-18. These cytokines regulate hepatic cell interaction and crosstalk of the various inflammatory pathways and influence disease outcome.
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