Journal
IMMUNOLOGICAL REVIEWS
Volume 269, Issue 1, Pages 118-129Publisher
WILEY
DOI: 10.1111/imr.12380
Keywords
Age-associated B cell; autoimmunity; T-BET; TLR7; TLR9; CD11c
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI118691, T32AI055428] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG030227, R01AG016841] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI118691, T32 AI055428] Funding Source: Medline
- NIA NIH HHS [R01 AG016841, R01 AG030227] Funding Source: Medline
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A subset of B cells with unique phenotypic and functional features-termed Age-associated B cells (ABCs)-has recently been identified in both mice and humans. These cells are characterized by a T-BET driven transcriptional program, robust responsiveness to TLR7 and TLR9 ligands, and a propensity for IgG(2a/c) production. Beyond their age-related accumulation, these cells play roles in both normal and pathogenic humoral immune responses regardless of host age. Thus, B cells with the ABC phenotype and transcriptional signature appear during viral, bacterial, and parasitic infections, but also arise during humoral autoimmune disease in both mouse models and humans. These observations suggest that both autoantigens and certain classes of pathogens provide the signals required for ABC differentiation. Herein, we review the discovery and features of ABCs, and propose that they are a memory subset generated by nucleic acid-containing antigens in the context of a promoting inflammatory cytokine milieu.
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