4.8 Article

Novel BODIPY-Based Fluorescence Turn-on Sensor for Fe3+ and Its Bioimaging Application in Living Cells

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 21, Pages 18408-18412

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/am506262u

Keywords

iron(III); fluorescent sensor; BODIPY; cryptand; cell imaging; metal ion sensor

Funding

  1. National Science Foundation [CHE-0832622]
  2. U.S. National Academy of Sciences [PGA-P210877]

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A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe3+ in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe3+-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe3+ detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe3+ in living cells.

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