Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 14, Pages 11025-11031Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am5016099
Keywords
electrochemical detection; surface enhanced Raman spectroscopy; doxorubicin; nanostructured Au modified ITO electrode
Funding
- National Key Basic Research Program [2010CB732404]
- National Natural Science Foundation of China [81325011, 21327902]
- National High Technology Research and Development Program of China [2012AA022703]
- Suzhou Science & Technology Major Project [ZXY2012028]
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Rapid and ultrasensitive detection of pathogenic bacteria and their relevant multidrug resistance is particularly important in clinical diagnosis, disease control, and environmental monitoring. In this contribution, we have explored the possibility to rapidly detect some important disease related bacteria based on a nanostructured Au modified indium tin oxide electrode through the antibiotic agents such as doxorubicin. The rapid and real-time electrochemical detection of multidrug resistant bacteria like Escherichia coli and Staphylococcus aureus could be readily realized through the nanostructured Au based biosensor with high sensitivity. The observations of surface-enhanced Raman spectroscopy and laser confocal fluorescence microscopy also demonstrate the effectiveness of the relevant new strategy for the rapid and ultrasensitive electrochemical detection of some disease related bacteria.
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