4.6 Review

Emerging roles of Lys63-linked polyubiquitylation in immune responses

Related references

Note: Only part of the references are listed.
Review Cell Biology

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

Lina Herhaus et al.

CELLULAR SIGNALLING (2014)

Article Medicine, Research & Experimental

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

Sayaka Inokuchi-Shimizu et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Immunology

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

Mary A. Rodgers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Multidisciplinary Sciences

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade

Xuefeng Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13

Peijing Zhang et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

Gloria Lopez-Castejon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Cell Biology

RNF168 forms a functional complex with RAD6 during the DNA damage response

Chao Liu et al.

JOURNAL OF CELL SCIENCE (2013)

Article Biochemistry & Molecular Biology

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

Benedicte F. Py et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis

Long Zhang et al.

MOLECULAR CELL (2013)

Review Immunology

Cell type-specific function of TAK1 in innate immune signaling

Adebusola A. Ajibade et al.

TRENDS IN IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

Su Myung Jung et al.

NATURE COMMUNICATIONS (2013)

Review Immunology

DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out

Kevin W. McCool et al.

IMMUNOLOGICAL REVIEWS (2012)

Review Immunology

Regulation of NF-κB by deubiquitinases

Edward W. Harhaj et al.

IMMUNOLOGICAL REVIEWS (2012)

Article Biochemistry & Molecular Biology

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

Christine Juliana et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

Takahito Sanada et al.

NATURE (2012)

Article Multidisciplinary Sciences

The mechanism of OTUB1-mediated inhibition of ubiquitination

Reuven Wiener et al.

NATURE (2012)

Article Multidisciplinary Sciences

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

Jae Hyang Lim et al.

NATURE COMMUNICATIONS (2012)

Review Cell Biology

Expanding role of ubiquitination in NF-kappa B signaling

Siqi Liu et al.

CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

Tao Huang et al.

EMBO JOURNAL (2011)

Review Immunology

RIG-I-like receptors: cytoplasmic sensors for non-self RNA

Hiroki Kato et al.

IMMUNOLOGICAL REVIEWS (2011)

Article Multidisciplinary Sciences

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Thomas Pertel et al.

NATURE (2011)

Review Immunology

Expanding TRAF function: TRAF3 as a tri-faced immune regulator

Hans Haecker et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Review Microbiology

Activation of host pattern recognition receptors by viruses

Kiva Brennan et al.

CURRENT OPINION IN MICROBIOLOGY (2010)

Article Biochemistry & Molecular Biology

E2 Polyubiquitin-conjugating Enzyme Ubc13 in Keratinocytes Is Essential for Epidermal Integrity

Koji Sayama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Shinichiro Nakada et al.

NATURE (2010)

Article Multidisciplinary Sciences

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

Kei-ichiro Arimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Editorial Material Multidisciplinary Sciences

Turning Off Inflammation Signaling

Srividya Sriskantharajah et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

Noula Shembade et al.

SCIENCE (2010)

Review Immunology

Regulation and Function of NF-kappa B Transcription Factors in the Immune System

Sivakumar Vallabhapurapu et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Review Genetics & Heredity

Ubiquitin-binding domains and their role in the DNA damage response

Kay Hofmann

DNA REPAIR (2009)

Article Biochemistry & Molecular Biology

The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain

Florence Cordier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Cell Biology

Looking beyond death: a morphogenetic role for the TNF signalling pathway

Sam J. Mathew et al.

JOURNAL OF CELL SCIENCE (2009)

Review Biochemistry & Molecular Biology

Nonproteolytic Functions of Ubiquitin in Cell Signaling

Zhijian J. Chen et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

Wenwen Zeng et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

Michael Stilmann et al.

MOLECULAR CELL (2009)

Editorial Material Biochemistry & Molecular Biology

A PAR-SUMOnious Mechanism of NEMO Activation

Kevin McCool et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes-Alnemri et al.

NATURE (2009)

Article Multidisciplinary Sciences

Direct activation of protein kinases by unanchored polyubiquitin chains

Zong-Ping Xia et al.

NATURE (2009)

Article Multidisciplinary Sciences

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung et al.

NATURE (2009)

Article Cell Biology

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

Fuminori Tokunaga et al.

NATURE CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

E2 interaction and dimerization in the crystal structure of TRAF6

Qian Yin et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13

Xuefeng Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Chemistry, Medicinal

Leucettamol A: A new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis

Sachiko Tsukamoto et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Article Biochemistry & Molecular Biology

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

Kim Newton et al.

Review Biochemistry & Molecular Biology

TGFβ in cancer

Joan Massague

Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

Review Biochemistry & Molecular Biology

Regulatory T cells and immune tolerance

Shimon Sakaguchi et al.

Article Biochemistry & Molecular Biology

Regulation of IκB kinase-related kinases and antiviral responses by tumor suppressor CYLD

Minying Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Immunology

An antiinflammatory role for IKKβ through the inhibition of classical macrophage activation

Carol Ho Yan Fong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Biochemistry & Molecular Biology

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β

Motozo Yamashita et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

Signal processing by its coil zipper domain activates IKKγ

Stuart Bloor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin

Haopeng Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

Atsushi Matsuzawa et al.

SCIENCE (2008)

Review Immunology

Deubiquitylation and regulation of the immune response

Shao-Cong Sun

NATURE REVIEWS IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

Bin Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

DUBA: A deubiquitinase that regulates type I interferon production

Nobuhiko Kayagaki et al.

SCIENCE (2007)

Review Genetics & Heredity

Many faces of NF-KB signaling induced by genotoxic stress

Zhao-Hui Wu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2007)

Article Multidisciplinary Sciences

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

Toru Fukushima et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Immunology

Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling

Masahiro Yamamoto et al.

JOURNAL OF IMMUNOLOGY (2006)

Article Multidisciplinary Sciences

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates

Andreas Pichlmair et al.

SCIENCE (2006)

Review Biochemistry & Molecular Biology

Ubiquitin-binding domains

James H. Hurley et al.

BIOCHEMICAL JOURNAL (2006)

Article Immunology

Rescue of TRAF3-null mice by p100 NF-κB deficiency

Jeannie Q. He et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Biochemistry & Molecular Biology

A ubiquitin ligase complex assembles linear polyubiquitin chains

Takayoshi Kirisako et al.

EMBO JOURNAL (2006)

Article Cell Biology

PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress

Angela M. Mabb et al.

NATURE CELL BIOLOGY (2006)

Article Immunology

NF-κB activation:: nondegradative ubiquitination implicates NEMO

Alain Israel

TRENDS IN IMMUNOLOGY (2006)

Article Biochemistry & Molecular Biology

ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity

T Takeuchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin

WG Zou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Cell Biology

AP-1 as a regulator of cell life and death

E Shaulian et al.

NATURE CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice

CH Régnier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

The tripartite motif family identifies cell compartments

A Reymond et al.

EMBO JOURNAL (2001)

Article Multidisciplinary Sciences

Mammalian MAP kinase signalling cascades

LF Chang et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3

MJ Servant et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)