Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 6, Pages 4301-4309Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am406061x
Keywords
silicon nanoparticle; red fluorescent probe; polyglycerol; RGD peptide; bioimaging
Funding
- CSIR
- DST
- DBT, government of India
- CSIR, India
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Here we report a surface modification approach for fluorescent silicon nanoparticle that transforms hydrophobic nanoparticle into water-soluble nanoparticle of high colloidal stability. The approach involves ring-opening polymerization of glycidol at the hydroxyl-terminated nanoparticle surface that results in a hyperbranched polyglycerol grafted silicon nanoparticle (Si-HPG). The resultant Si-HPG has 25 nm hydrodynamic diameter, low surface charge, and broad emission in the range of 450-700 nm with a fluorescence quantum yield of 6-9%. The Si-HPG has been transformed into cyclic RGD peptide functionalized nanoprobe using the conventional bioconjugation chemistry and used for specific targeting to alpha(v)beta(3) integrin overexpressed cervical cancer cells and glioblastoma cells. Result shows that a silicon nanoparticle-based red fluorescent nanoprobe can be developed for in vitro/in vivo bioimaging applications.
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