Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 13, Pages 10476-10481Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am502458h
Keywords
layer-by-layer; autonomous motor; Janus capsules; biocatalysis; remote release
Funding
- National Nature Science Foundation of China [91027045, 21103034]
- 100-Talent Program of HIT, New Century Excellent Talent Program [NCET-11-0800]
- State Key Lab of Urban Water Resource and Environment in HIT [ESK201302]
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We present herein a novel hybrid, polymer-based motor that was fabricated by the template-assisted polyelectrolyte layer-by-layer (LbL) deposition of a thin gold layer on one side, followed by chemical immobilization of a catalytic enzyme. Such Janus capsule motors can self-propel at 0.1% peroxide fuel concentration at physiological temperature and have a higher speed as compared to Pt-based synthetic motors. They were exploited for encapsulation of the chemotherapeutic anticancer drug, doxorubicin, for navigation to target a cell layer by an external magnetic field, and for triggered drug release activated by NIR light. This work provides high potential in the development of multifunctional polymer-based engines for biomedical applications such as targeted drug delivery.
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