Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 11, Pages 8401-8406Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am501309d
Keywords
angiogenesis; decellularization; extracellular matrix; copper-catalyzed click chemistry; QK peptide
Funding
- National Institutes of Health (NIH) [R21HD058985]
- National Science Foundation (NSF) [DMR-0706627, DMR-1207583]
- The Alliance for NanoHealth [W81XWH-09-02-0139]
- China Scholarship Council [2010615034]
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We show that coating of decellularized extracellular matrix (DC-ECM) on substrate surfaces is an efficient way to generate a platform mimicking the native ECM environment. Moreover, the DC-ECM can be modified with a peptide (QK) mimicking vascular endothelial growth factor without apparently compromising its integrity. The modification was achieved through metabolic incorporation of a clickable handle to DC-ECM followed by rapid attachment of the QK peptide with an azido tag using copper-catalyzed click reaction. The attachment of the QK peptide on to DC-ECM in this way further enhanced the angiogenic responses (formation of branched tubular networks) of endothelial cells.
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