Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 10, Pages 7719-7727Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am500980z
Keywords
upconversion nanoparticle; hyperbranched polyglycerol; water dispersibility; surface functionality; bioimaging
Funding
- National Natural Science Foundation of China [51103028, 21364003]
- Guangxi Natural Science Foundation [2012GXNSFBA053152, 2013GXNSFDA019008]
- Innovation Project of Guangxi Graduate Education [YCSZ2014150]
- Guangxi Funds for Specially-appointed Expert and Guangxi Small Highland Innovation Team of Talents in Colleges and Universities
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Upconversion nanoparticle (UCNP) as a new class of imaging agent is gaining prominence because of its unique optical properties. An ideal UCNP for bioimaging should simultaneously possess fine water dispersibility and favorable functional groups. In this paper, we present a simple but effective method to the synthesis of a UCNP-based nanohybrid bearing a multihydroxy hyperbranched polyglycerol (HPG) shell by the combination of a grafting from strategy with a ring-opening polymerization technique. The structure and morphology of the resulting UCNP-g-HPG nanohybrid were characterized in detail by Fourier transform infrared, H-1 NMR, thermogravimetric analysis, and transmission electron microscopy measurements. The results reveal that the amount of grafted HPG associated with the thickness of the HPG shell can be well tuned. UCNP-g-HPG shows high water dispersibility and strong and stable upconversion luminescence. On the basis of its numerous surface hydroxyl groups, UCNP-g-HPG can be tailored by a representative fluorescent dye rhodamine B to afford a UCNP-g-HPG-RB nanohybrid that simultaneously presents upconversion and downconversion luminescence. Preliminary biological studies demonstrate that UCNP-g-HPG shows low cytotoxicity, high luminescent contrast, and deep light penetration depth, posing promising potential for bioimaging applications.
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