Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 17, Pages 14795-14800Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am504791b
Keywords
DNA; gold nanoparticles; phosphorothioate; adsorption; self-assembly; nanotechnology
Funding
- University of Waterloo
- Natural Sciences and Engineering Research Council of Canada
- Foundation for Shenghua Scholar of Central South University
- National Natural Science Foundation of China [21301195]
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Unmodified DNA was recently used to functionalize gold nanoparticles via DNA base adsorption. Compared to thiolated DNA, however, the application of unmodified DNA is limited by the lack of sequence generality, adsorption polarity control and poor adsorption stability. We report that these problems can be solved using phosphorothioate (PS) DNA. PS DNA binds to gold mainly via the sulfur atom and is thus less sequence dependent. The adsorption affinity is ranked to be thiol > PS > adenine > thymine. Tandem PS improves adsorption strength, allows tunable DNA density, and the resulting conjugates are functional at a low cost.
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