Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 9, Pages 6281-6289Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am4045212
Keywords
3D biomimetic SERS substrate; hotspots; nanogaps; cicada wings; label-free virus detection
Funding
- National Natural Science Foundation of China [21175051]
- Natural Science Foundation of Hubei Province Innovation Team [2011CDA115]
- Fundamental Research Funds for the Central Universities [2012SC04, 2013SC17]
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A three-dimensional (3D) biomimetic SERS substrate with hierarchical nanogaps was formed on the bioscaffold arrays of cicada wings by one-step and reagents-free ion-sputtering techniques. This approach requires a minimal fabrication effort and cost and offers Ag nanoislands and Ag nanoflowers with four types of nanogaps (< 10 nm) on the chitin nanopillars to generate a high density of hotspots (similar to 2000/mu m(2)). The 3D biomimetic substrate shows a low detection limit to Rhodamine 6G (10(-13) M), high average enhancement factor (EF, 5.8 X 10(7)), excellent signal uniformity (5.4%), good stability, and suitability in biosensing. Furthermore, the finite-difference time-domain (FDTD) electric-field-distribution simulations illustrate that the 3D biomimetic SERS substrate provides the high-density hotspot area within a detection volumem, resulting in enormous SERS enhancement. In addition, the conspicuous far-field plasmon resonance peaks were not found to be a strong requirement for a high EF in 3D biomimetic substrates. Additionally, the novel substrate was applied in label-free animal virusesdetection and differentiation with small amounts (1.0 mu L) and low concentrations of analyte (1 x 10(3) PFU/mL), and it exhibited potential as an effective SERS platform for virus detection and sensing.
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