Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 6, Issue 10, Pages 7948-7952Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am501275t
Keywords
supermolecular; hydrogels; self-assemble; cell culture; migration; three dimensional
Funding
- NSFC [51273111, 51173105]
- National Basic Research Program of China (973 Program) [2012CB933803]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Research Fund for the Doctoral Program of Higher Education of China
- SRF for ROCS, SEM
- Shanghai Jiaotong Medical/Engineering Foundation [YG2012MS29]
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A convenient three-dimensional cell culture was developed by employing high swelling property of hybrid hydrogels coassembled from C-2-phenyl-based supermolecular gelators and sodium hyaluronate. Imaging and spectroscopic analysis by scanning electron microscopy (SEM), atomic force microscopy (AFM), transform infrared (FT-IR) spectra confirm that the hybrid gelators can self-assemble into nanofibrous hydrogel. The high swelling property of dried gel ensures cell migration and proliferation inside bulk of the hydrogels, which provides a facial method to study disease models, the effect of drug dosages, and tissue culture in vitro.
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