Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 17, Pages 8263-8266Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am402086m
Keywords
photoresponsive; nanohybrids; 2-mercapto-5-nitrobenzimidazole (MNBI); gold nanoparticles (GNP); nitric oxide (NO); apoptosis
Funding
- CSIR, New Delhi
- CSIR [NWP0035, M2D]
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Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was found that even a very low dosage of MNBI-stabilized GNPs exhibit appreciable tumor cell mortality against cervical cancer cell lines, demonstrating the role of NO in killing cancer cells.
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