4.8 Article

Facile Incorporation of Aggregation-Induced Emission Materials into Mesoporous Silica Nanoparticles for Intracellular Imaging and Cancer Therapy

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 5, Issue 6, Pages 1943-1947

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/am302512u

Keywords

aggregation-induced emission; mesoporous silica nanoparticles; cell imaging; cancer therapy; drug delivery; biomedical applications

Funding

  1. National Science Foundation of China [21134004, 21104039, 21201108]
  2. National 973 Project [2011CB935700]
  3. China Postdoctoral Science Foundation [2011M500280, 2012 M520243]

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Aggregation-induced emission (ALE) materials were facilely incorporated into mesoporous silica nanoparticles (MSNs) via one-pot surfactant templated method. Cell imaging and cancer therapy applications of such fluorescent MSNs were further explored. We demonstrated that AIE-MSN nanocomposites showed strong fluorescence and uniform morphology, making them promising for both cell imaging and cancer therapy.

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